Analysis on the correlative factors and therapeutic efficacy of secondary high intraocular pressure after vitreoretinal surgery for proliferative diabetic retinopathy

1. Dr Song Chen
2. Li-zhu Meng

Tianjin Eye Hospital

Objective To discuss the correlative factors and therapeutic efficacy of secondary high intraocular pressure(IOP) after vitreoretinal surgery (VRS)for proliferative diabetic retinopathy£¨PDR£©Methods 161 eyes of 136 consecutive patients with type 2 PDR were analyzed retrospectively. The IOP, retinal anatomic reattachment and best-corrected visual acuity(BCVA) were observed.Multivariate analysis with logistic regression was used to determine the influencing factors of high IOP after VRS.

Results Forty-three eyes of 43 patients experienced postoperative high IOP, with the incidence of 26.7%% (43/161). Multivariate logistic regression revealed postoperative inflammatory reaction (OR=3.027) and fasting blood glucose(FBG) (OR=2.866)were two independent risk factors to lead to high IOP. However, it was not related to the practice of intraocular tamponade, the combined performance of crystal surgery and scleral buckle.The mean(¡Àstandard deviation) IOP was 34.26¡À8.76 mmHg pretherapy, 17.44¡À3.79 mmHg post-therapy and 15.58¡À3.80mmHg after an average follow-up of 22.93¡À10.16 months (P<0.05for all).Before the high IOP development the BCVA was no light perception(NLP) to 0.08,while at the final follow-up visit it was NLP to 0.7.

Conclusion Postoperative inflammatory reaction and FBG were two independent risk factors that induce high IOP. Part of vision can be recovered only if high IOP can be controlled effectively with timely individualized therapy.