Comparison Of Post Op Endophthalmitis Prophylaxis Using Two Different Drugs

1. Ayisha Shakeel¹, MCPS, MRCOphth (London), FRCS (Glasgow)
2. Mudassar Bukhari¹, DO

¹Layton Rehmatullah Benevolent Trust, Karachi, Pakistan

Purpose: The purpose of this study is to compare the effectiveness of intracameral cefuroxime and moxifloxacin in preventing postop endophthalmitis.

Methods: Patients were randomly distributed in three groups. One group underwent routine aseptic technique of phacoemulsification without intracameral antibiotic injection of any kind. The second group received an additional intracameral cefuroxime injection in the dose of 1mg/0.1ml. The third group received intracameral moxifloxacin instead at the end of surgery. Statistical techniques were used to analyse the data and to assess any difference in the outcome of the procedure.

Results: Initial results reflect that there are fewer cases of post op endophthalmitis following intracameral antibiotic injections. However both drugs appear to work equally effective in preventing post op endophthalmitis. It is important to highlight that cefuroxime is approximately three times cheaper as compared to moxifloxacin

Conclusion: Inj cefuroxime owing to its significantly lower cost can be effectively used in the prevention of post op endophthalmitis in poor countries with high frequency of cataract surgeries.