Intracameral Levofloxacin Eye Drops in Preventing Post Operative Endophthalmitis

1. Soedarman Sjamsoe^1,2
2. Made Susiyanti^1,2
3. Johan Hutauruk^1,2
4. Rina La Distia Nora²
5. Arini Setiawati³

¹Jakarta Eye Center, Jakarta, Indonesia
²Department of Ophthalmology, University of Indonesia, Dr Cipto Mangunkusumo
Hospital,Jakarta, Indonesia
³Department of Pharmacology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia

Methods: a prospective randomized controlled partially masked trial. 64 patients were randomized into a study group who received 0.5ml/0.1 mL intracameral levofloxacin ophthalmic solution as the last step of phacoemulsification, and a control group who received intracameral BSS post uneventful phacoemulsification.

Main outcome measures : corneal endothelial cell density, corneal thickness and anterior chamber reaction. Their value in the 7th day and the 28th day post operation were compared to the pre operation values. Different ophthalmologists conducted the postoperative evaluation in an observer-masked fashion. P value less than 0.05 was considered significant.

Results &Conclusions :No significant difference of endothelial cell density, corneal thickness and anterior chamber reaction between the study and control group. Intracameral levofloxacin a broader spectrum of antimicrobial activity and more safe and simple to prepare. It is safe to use intracameral levofloxacin as prophylaxis.
Further studies to prove its effectiveness in preventing endophthalmitis.