Correlations And Possible Risk Profiling Of Biometric Parameters In Subjects With Primary Angle Closure Glaucoma.

1. Vinay Nangia1
2. Rajesh Gupta¹
3. Anshu Khare¹
4. Shubhra Agarwal¹
5. Karishma Bhate¹

¹Suraj Eye Institute, Nagpur. India.

Purpose: Biometric parameters of axial length, lens thickness and anterior chamber depth are considered to be important in the aetiopathogenesis of primary angle closure glaucoma. It was the purpose to determine the ocular correlations of these biometric parameters and create a relative risk profile for them in primary angle closure disease.

Method: 92 eyes of 45 subjects with PACG were included. There were 16 males and 30 females. The mean age was 57.91+12.03yrs. Visual Acuity was recorded in Digital units. (6/6=1). All subjects underwent an ophthalmic evaluation, including, gonioscopy and biometry using sonography.

Results: The mean axial length was 22.23+0.81mm, the lens thickness was 4.49+0.71 and the anterior chamber depth was 2.56+0.54mm. Axial length was not significantly correlated with anterior chamber depth (P=0.238;r=0.127) and lens thickness (p=0.568,r=0.061). It was positively significantly correlated with height (P=0.004,r=0.399), weight (P<0.001,r=0.511), vertical corneal curvature (P<0.001,r=-0.641), horizontal corneal curvature (P<0.001, r=-0.616), central corneal thickness (p=0.029,r=0.278) and spherical equivalent (p=0.007,r=
-0.320). The lens thickness was not correlated with any of the above parameters. The anterior chamber depth was correlated with spherical equivalent (p=0.001,r=-0.40).

Discussion: The axial length was correlated with several ocular and systemic parameters but not with lens thickness and anterior chamber depth in PACG. The lens thickness was not correlated with any ocular and systemic parameter and appeared to be independant. These findings may be important in explaining the role of each of the biometric parameters individually in the development of primary angle closure disease.