Comparison of Macular Sensitivity in Early and Moderate Stage Open-angle And Angle-closure Glaucoma with Microperimetry

1. Ping Huang¹
2. Yan Shi¹
3. Xin Wang¹
4. Samuel Shao-Min Zhang²
5. Chun Zhang¹

¹Department Of Ophthalmology, Peking University Third Hospital
²Department of Neural and Behavioral Sciences, Penn State Hershey Eye Center, Penn State University College of Medicine

PURPOSE: To measure and compare macular light sensitivity in early and moderate primary open angle glaucoma (POAG), chronic angle closure glaucoma (CACG), and normal controls with MP-1 microperimetry.

METHODS: A total of 126 eyes from 113 subjects including 53 normal eyes, 50 POAG eyes and 23 CACG eyes were prospective enrolled in this study. Subjects with Mean defect (MD) of the standard automatic perimetry (SAP) no worse than 10 dB were enrolled in this study. Macula 10° program with 40 stimuli was performed with MP-1 microperimetry. The mean sensitivity of central1°, 3°, and 5° visual field were calculated and compared among POAG, CACG, and normal controls respectively. Correlation analysis between mean sensitivity in MP-1 and mean defect in SAP was performed.

RESULTS: The average light sensitivity at central 1°, 3°, 5°, and total macular area in POAG patients was significantly decreased compared to normal controls, respectively (p=0.000, p=0.000, p=0.000, p=0.004). The average sensitivity at central 3° (p=0.004), 5° (p=0.013) and total (p=0.024) in CACG patients were significantly declined compared to normal controls. However no significant difference at central 1° was observed in CACG patients (p=0.145) compared to normal controls. Macular sensitivity was significantly correlated with mean defect in SAP in POAG (p<0.05 at central 3°, 5° and total area respectively). But this correlation was only found at central 5° in CACG (p<0.05).

CONCLUSIONS: The amount of macular sensitivity reduction is different between POAG and CACG, which provides new evidence to the distinct pathogenesis between POAG and CACG.