One-year result of choroidal thickness following photodynamic therapy in central serous chorioretinopathy

1. Ichiro Maruko
2. Yukinori Sugano
3. Akira Ojima
4. Hiroshi Oyamada
5. Tetsuju Sekiryu
6. Tomohiro Iida

Fukushima Medical University School of Medicine

(Purpose)
Subfoveal choroidal thickness decreased after photodynamic therapy (PDT) in 3 months.1) To evaluate choroidal thickness 1 year after PDT in the eyes with central serous chorioretinopathy (CSC) using optical coherence tomography (OCT).

(Methods)
Eight eyes of eight patients (average 61-year-old) with chronic CSC were observed in one year following half-dose verteporfin PDT. All eyes were diagnosed using fluorescein angiography, and the choroidal vascular hyperpermeability was evaluated by indocyanine green angiography. We measured the subfoveal choroidal thickness using enhanced depth imaging (EDI) OCT.

(Results)
Mean subfoveal choroidal thickness significantly decreased from 377 ± 117μm at baseline to 291 ± 143μm at 1 month, 277 ± 143μm at 3 months, 276 ± 145μm at 6 months, 280 ± 155μm at 1 year (each P<0.02). On the other hand, choroid significantly thickened in 2 days after PDT (433 ± 140μm, P=0.04). There was no patient with recurrence. Indocyanine green angiography images in 3 months showed the less choroidal vascular hyperpermeabilty compared to baseline.

(Conclusions)
Choroidal thinning 1 month after PDT continued for 1 year. Half-dose verteporfin PDT for chronic CSC decreased the choroidal vascular hyperpermeability and maintain in 1 year. EDI-OCT was helpful in monitoring the pathophysiological choroidal changes in CSC.
1) Maruko I, et al. Ophthalmology, 2010.