Relationship between IgG4-related chronic sclerosing dacryoadenitis and Castleman disease

1. Toshiyuki Oshitari
2. Jiro Yotsukura
3. Kaoru Asanagi
4. Takashi Kishimoto
5. Shuichi Yamamoto

1. Chiba University Graduato School of Medicine, Chiba, Japan

Purpose. To present a case of IgG4-related chronic sclerosing dacryoadenitis in a patient who diagnosed earlier with Castleman disease.

Methods. A 79-year-old man noticed a swelling his left jaw that was first seen 8 years earlier. He was diagnosed with Castleman disease from the histopathological examination of a biopsy of the submandibular gland. Since then, the size of the gland had not changed, and he had no systemic inflammatory signs or symptoms. He developed diplopia a year earlier, and CT scans showed bilateral swelling of the lacrimal glands. He was referred to our hospital for further examinations.

Results. The patient underwent partial dacryoadenectomy. From the histopathological examinations, he was diagnosed with IgG4-related chronic sclerosing dacryoadenitis. He underwent oral steroid therapy and the swollen lacrimal glands were significantly improved.

Conclusion. These results suggest that there may be pathological link between IgG4-related dacryoadenitis and Castleman disease.