|
 |
 |
|
Ophthalmologic Outcomes of Nonconjunctival Ocular Adnexal MALT Lymphoma Suk-Woo Yang¹, So-Youl Kim², Ji-Sun Paik¹, Won-Kyung Cho¹ ¹Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea Purpose: To evaluate ophthalmologic outcomes after radiation therapy or chemotherapy in patients with nonconjunctival ocular adnexal MALT lymphoma and to evaluate the validity of these criteria (ophthalmologic outcomes) to assess ophthalmologic symptoms after radiation or chemotherapy. Method: Ophthalmologic outcomes were assessed in patients who have received radiation therapy, chemo-radiation therapy or chemotherapy from August, 2005 until May, 2009. They were devised based on common symptoms followed by radiation therapy and chemotherapy which were consisted of the state of visual acuity, dry eye symptoms, lens opacity, intraocular pressure, and blepharitis. We assessed each patient with these criteria after treatment schedule complete and every three months after then. Results: 12 patients were included. 7 patients received radiation therapy only, 4 patients received combination chemotherapy, and 1 patient combination chemotherapy with additional radiation therapy. The patients treated by chemotherapy were in more advanced stages(one patient-IIE, one patient-IVE) but they showed better ophthalmologic outcomes score (score 0~3) than the patients treated by radiation or chemoradiation therapy (8 patients-stage IE, 3 patients-score 6, one patient-5, one patient-4). Conclusions: Nonconjunctival MALT lymphoma are known as more aggressive disease state than conjunctival lesion. Recently besides radiotherapy and chemotherapy, many new treatment options have emerged such as immunotherapy or bacteria eradicating therapy. To select treatment modality more stable and following less complications well designed prospective trials with ophthalmologic outcomes will be needed. In this point of view, our ophthalmologic outcomes are good to compare between radiation therapy and chemotherapy. |
 |