Efficacy and safety of implants used in the anophthalmic socket reconstruction: systematic review of clinical trials on integrated versus nonintegrated implants

Silvana Schellini

Purpose: To evaluate the efficacy and safety of the integrated versus not integrated implants in the anophthalmic socket reconstruction using a systematic review or metanalysis

Methods: Type of study evaluated: randomized clinical trials and almost randomized. Search strategy: We investigated the following databases: Pubmed (1966 - 2010), registration Supervised trials of Cochrane Collaboration, CENTRAL (2010, edition 3), Embase (1980 - 2010), Lilacs (1982 - 2010) and metaRegister of Controlled Trials (mRCT) (2010). The date of the last search was August 01, 2010. Criterion for selection of studies: randomized clinical trials and almost randomized studies that evaluated integrated versus not integrated implants in the anophthalmic socket reconstruction. Analysis and data collection: Two auditors selected relevant studies and evaluated the methodological quality.

Results: Only a clinical trial was considered in this review. Thirty-one studies were listed in table of exclusion for treat studies series of cases, retrospective and controlled studies.

Conclusions: There is no evidence at this time to determine the efficacy and safety of integrated and not integrated implants in the reconstruction of anophthalmic cavity. Clinical trials well designed, with outcomes presented in the protocol of systematic review must be implemented immediately.