Study Of The Safety And Effectiveness Between Ologen™ Collagen Matrix Implant And Mitomycin-C In Standard Glaucoma Filtration Surgery

1. Syed Imtiaz Ali¹
2. Nadeem Hafeez Butt
3. Imran Asif
4. Syed Mustafa Ali

¹Benazir Bhutto Hospital, Rawalpindi, Pakistan

Purpose:
To evaluate the efficacy and safety of collagen matrix implant in trabeculectomy comparing with patients undergoing trabeculectomy with Mitomycin-C.

Methods:
In this non-randomized, parallel clinical trial 22 eyes were categorized into two groups, each comprising 11 eyes. Group A comprised patients that received trabeculectomy with Collagen Matrix implant (ologenTM)

Results:
Mean pre-operative IOP was 35.33mmHg (21 -55mmHg) in Group A versus 34.6mmHg (21 – 45mmHg) in Group B. On day 30th the mean IOP in Group A was 11.5mmHg (5-30mmHg) vs. 13.37mmHg (2-40mmHg) in Group B

Conclusion:
Implantation of Collagen Matrix implant (Ologen™) effectively brings IOP under control through the formation of a loosely structured filtering bleb. This device may represent a safe, simple and effective therapeutic approach for treating refractory glaucoma without determined complications seen using adjunctive therapy