Trabeculectomy Using Biodegradable Collagen Matrix Implant in Chronic Primary Glaucoma Patients: A Preliminary Study

Astrianda NS, Edi Supiandi, Ikke Sumantri, Rianto Setiabudy

Department of Ophthalmology, Faculty of Medicine, University of Indonesia

Purpose:
To evaluate the outcomes of trabeculectomy using biodegradable collagen matrix (BCM) implant in chronic primary glaucoma patients

Methods:
A prospective interventional preliminary study was conducted. Trabeculectomy using BCM implants were done in 10 eyes. Intraocular measurements as well as bleb morphology grading using photography and the Moorfields Bleb Grading System were done on day 7, 14, 28 and 56 post operatively. Bleb analysis using anterior segment optical coherence tomography (AS-OCT) were done on day 28 and 56 post operatively.
Possible complications were to be evaluated.

Results:
Ten patients were followed-up for 2 months: 80% were classified as successful, 10% failure, 10% excluded due to incomplete follow up. Mean IOP were 15.8 mmHg, with mean reduced IOP of 14.2 mmHg. Majority of successful bleb showed high subconjunctival cavity with micro-hiporeflective spaces in the bleb wall. The bleb height obtained by photography were not in full agreement with height obtained by AS-OCT. No complications were found in all patients at all times.

Conclusions:
Trabeculectomy with BCM implant showed a tendency to maintain a good IOP with the presence of characteristics found in functioning blebs characteristics for up to 2 months post operative.

Keywords: biodegradable collagen matrix, bleb analysis