Fluorescein Angiography Patterns Associated With The Effect Of Intravitreal Bevacizumab Injection For Diabetic Macular Edema

1. Chulgu Kim¹
2. Hyeongsuk Kim¹

¹Kim's Eye Hospital, Seoul, Republic of Korea

Purpose
To analyze the fluorescein angiography (FA) findings associated with the effect of intravitreal bevacizumab injection (IVB) for treatment of diabetic macular edema (DME).

Methods
Sixty eyes of 55 patients with DME were included in this prospective, non-randomized pilot study. The changes in best-corrected visual acuity (BCVA) and central macular thickness (CMT) on optical coherence tomography were evaluated considering the FAG pattern at baseline and 3 month after IVB.

Results
On baseline FA, 16 eyes (26.7%) showed honeycomb type hyperfluorescence; 9 eyes (15.0%), petaloid type; and 35 eyes (58.3%), diffuse type. Three months after IVB, the mean decrease in CMT was 250.6 ± 204.17 μm in the case of the honeycomb and petaloid type, which was significantly larger than that in the case of the diffuse type 102.5 ± 175.24 μm (p = 0.03). The improvement in BCVA was 0.26 ± 0.53 logMAR in the case of the honeycomb and petaloid type and 0.16 ± 0.48 logMAR in the case of the diffuse type; this difference was statistically significant (p < 0.02). There was no statistical relationship between the leakage starting time and CMT or BCVA.

Conclusions
The effect of IVB for treatment of DME was better in eyes showing honeycomb and petaloid type hyperfluorescence on baseline FAG than those exhibiting diffuse type hyperfluorescence.