Fig. 23 A. Fifty-two-year-old man with clinically significant macular edema and a partial circinate ring of hard exudates. B. Midphase of the fluorescein angiogram shows a cluster of microaneurysms in the center of the are a edema. C. Late phase shows severe leakage. D. Several months after treatment, the edema is no longer present and the visual acuity is 20/25.