Fig. 24. Diffuse lamellar (interface) keratitis. A. In stage 2, the accumulated white blood cells often cluster along the “chatter lines” created by the microkeratome blade oscillation. B. As the intensity progresses, in stage 3 the visualization of the anterior chamber is reduced. C. In the most advanced stage 4, release of collagenase causes softening and even loss of corneal stroma from the flap and underlying bed, accompanied by flap wrinkling.