Fig. 5. A hypothetical scheme for horizontal smooth pursuit. Primary visual cortex (V1) projects to the homologue of the middle temporal visual area (MT) that, in humans, lies at the temporal-occipital-parietal junction. MT projects to the homologue of the medial superior temporal visual area (MST) and also to the frontal eye field (FEF). MST also receives inputs from its contralateral counterpart. MST projects through the retrolenticular portion of the internal capsule and the posterior portion of the cerebral peduncle to the dorsolateral pontine nucleus (DLPN). The DLPN also receives inputs important for pursuit from the frontal eye field; these inputs descend in the medial portion of the cerebral peduncle. The DLPN projects, mainly contralaterally, to the flocculus, paraflocculus and ventral uvula of the cerebellum; projections also pass to the dorsal vermis. The flocculus projects to the ipsilateral vestibular nuclei (VN), which in turn project to the contralateral abducens nucleus. Note that the sections of brainstem are in different planes from those of the cerebral hemispheres. (Modified from Leigh RJ, Zee DS. The Neurology of Eye Movements, 3rd ed. New York: Oxford University Press, 1999)