Fig. 15. A. Clinical photograph of Pfeiffer's syndrome demonstrating exophthalmos, hypertelorism, small mandible, “parrot-beak” nose, recessed supraorbital ridges, and increased forehead height. B. Enlarged thumb of same patient. C. Broad, long great toe. (Fries PD, Katowitz JA: Congenital craniofacial anomalies of ophthalmic importance. Surv Ophthalmol 35:87, 1990, with permission from Elsevier Science.)