Fig. 19. Cholinergic denervation supersensitivity in a patient with a compressive third nerve palsy affecting the left eye. A. Before instillation of 0.1% pilocarpine, right pupil measured 5 mm and left pupil measured 6 mm in darkness using a Polaroid CU-5 (Polaroid Corp., Cambridge, MA) camera with 1:1 magnification. B. Thirty minutes after instillation of 0.1% pilocarpine, right pupil measured 2.2 mm and left pupil measured 1.8 mm in darkness, indicating denervation supersensitivity of the left pupil. The left pupil thus demonstrated denervation supersensitivity by both of the commonly used clinical criteria.