Fig. 10. Phylogenetic tree of coxsackievirus A24 genotypes isolated from acute hemorrhagic conjunctivitis, indicating evolution from a hypothetical ancestral strain (*) that emerged in 1963, with subsequent worldwide spread after 1985 by various progenies of a single strain. (Ishiko H, Takeda N, Miyamura K, et al: Phylogenetic analysis of a coxsackievirus A24 variant: The most recent worldwide pandemic was caused by progenies of a virus prevalent around 1981. Virology 187:748, 1992).