Fig. 2. Pharmacokinetic parameters related to the MIC (minimum inhibitory concentration). As one increases the AUC (area under the curve), the time above the MIC and the peak: MIC and AUC: MIC ratios all increase as well. (Reprinted by permission from Appleton Lange, Stamford, CT: Principles of Therapeutic Drug Monitoring, third edition, by William E. Evans, Jerome J. Schentag, and William J. Jusko, published by Applied Therapeutics, Inc., Vancouver, Washington, 1992, Figure 97.11, p 1950.)