Fig. 5. Choroidal nevus versus melanoma. A. Partially melanotic and partially amelanotic choroidal tumor with prominent clumps of retinal pigment epithelial (RPE) pigment and drusen on surface. B-D. Fluorescein angiogram of lesion. B. Laminar venous phase frame showing poorly defined hypofluorescence of choroidal lesion and area of window defect hyperfluorescence corresponding to amelanotic portion of lesion. C. Full venous phase frame showing persistent mild hypofluorescence corresponding to melanotic portion of lesion, increased hypofluorescence corresponding to RPE thinning and drusen overlying lesion, and foci of intense hypofluorescence corresponding to RPE clumps on lesion. D. Late-phase frame showing persistence of features shown in the prior frames plus more numerous hyperfluorescent foci corresponding with additional drusen.