Fig. 15. Oculocerebrorenal syndrome of Miller. A. Rudimentary hypoplastic iris leaves and congenital cortical and nuclear cataract in the eye of a 6.5-month-old, mentally retarded, microcephalic child, who had a bilateral Wilms tumor (H&E, × 10 [AFIP Neg. 65-3904]). B and C. Different planes of a single section demonstrate a rudimentary iris with both uveal and neuroepithelial layers but lacking sphincter and dilator muscles (H&E, × 50 [AFIP Neg. 65-3910]). (Zimmerman LE, Font RL: Congenital malformations of the eye. JAMA 196:684, 1966)