Fig. 1. Granulation tissue. A. Clinical photograph of granulation tissue (often mistakenly called a pyogenic granuloma) at the site of a ruptured chalazion. B. Granulation tissue growth in the region of a chalazion. The tissue has responded by forming multiple fine-caliber vascular channels associated with an infiltrate of acute and chronic inflammatory cells. The lightly stained areas in the tissue represent the response of fibroblasts and vascular endothelial cells to alter and augment the extracellular matrix. (Hematoxylin-eosin stain; × 100.)