Fig. 19. Senile macular degeneration. A. Basophilia of the region of Bruch's membrane (arrows) is a common senile change. Note the partial obliteration of the choriocapillaris. Such aging changes may be precursors of some senile degenerations in the macular region. B and C. Fragile basophilic Bruch's membrane, which shows numerous cracks. B. Positive result (arrows) with a special stain to demonstrate the presence of calcium. D. Electron micrograph shows dark areas representing calcification in the region of Bruch's membrane. (A, H&E, ×395; B, von Kossa, ×252; C, H&E, ×252; D, ×20,000)