Fig. 33. Epithelioid melanoma cells. The cytoplasmic margins of these large, poorly cohesive epithelioid melanoma cells are easily discernible. Epithelioid cell nuclei are typically round and have peripheral margination of coarsely clumped chromatin. Epithelioid cells usually have prominent reddish purple nucleoli. They typically are polyhedral in shape and have copious amounts of cytoplasm. (Hematoxylin-eosin, × 250.)