Fig. 38. Necrotic uveal melanoma. The cells of this necrotic melanoma are eosinophilic because they have lost their basophilic nuclear DNA. The cell type of a necrotic melanoma often can be ascertained if careful microscopy with an oil-immersion lens is performed. Necrotic uveal melanomas tend to behave clinically like mixed cell type melanomas. (Hematoxylin-eosin, × 250.)