TABLE 2. Nonsterioidal Anti-Inflammatory Drugs and Inhibition of Intraoperative Miosis

Investigator (no. of patients) year NSAID Dose regimen Coexisting treatment Change in pupil diameter (mm)
Drug (no. of patients) Vehicle (no. of patients) Statistical significance*
Keulen-DeVos154 (64) 1983 Indomethacin 0.5% solution 1 gtt 7:00 PM and 9:00 PM night before surgery and 2, 1, and 1/4 hr before surgery 0.5% tropicamide, 5% phenylephrine −2.44 (32) −3.12 (32) p = 0.01
Keates153 (106) 1984 Indomethacin 1% suspension 1 gtt 5:00 PM and 9:00 PM night before surgery and 1 gtt 1, ¾, and ½ hr before surgery 1% tropicamide, 2.5% phenylephrine −0.27 (55) −0.84 (51) p = 0.001
Keates149 (34) 1984 Flurbiprofen 0.03% solution 1 gtt at 6:00 AM and 7:00 AM and 1, ¾, and ½ hr before surgery 1% tropicamide, 2.5% phenylephrine −2.5 (16) −3.9 (18) p = 0.003
Stark150 (412) 1986 Suprofen 1% solution 2 gtt every 4 hr the day before surgery, and 2 gtt every hr × 3 before surgery Variable and including intraoperative epinephrine in some cases −1.01 (209) −1.48 (203) p = 0.001


* All results favor nonsteroidal anti-inflammatory drug (NSAID) treatment over placebo.