TABLE 4. Nonsteroidal Anti-Inflammatory Drug Effects on Inflammation After Glaucoma Surgery


Authors (date) Procedure (no. of eyes) Drug (dosage) Results*
Cells Flare Conjunctival vasodilation Comment
Hotchkiss et al205(1984) Argon laser trabeculoplasty (70) 0.03% Flurbiprofen (5 gtt, then 1 gtt q.i.d. for 7 days) NS NS p < 0.005 Ocular discomfort with drug treatment as compared with placebo
Weinreb et al95 (1984) Argon laser trabeculoplasty (130) 0.03% Flurbiprofen (6 gtt, then 1 gtt every 20 min for 2 hr) NS NS p = 0.05† Fewer eyes in drug treated group had inflammation at 35 days. p = 0.024
Rohm et al147 (1987) Argon laser trabeculoplasty (80) 0.03% Flurbiprofen (6 gtt, then 1 gtt every 20 min for 2 hr) p < 0.05 day 1 p < 0.05 days 1, 7 p < 0.05 hour 3, day 1 5 Placebo-treated and 1 drug-treated had uncontrolled inflammation at 5 weeks
Hurvitz et al216 (1984) Cyclocryotherapy (39) 0.03% Flurbiprofen (2 gtt at 3, 2, & 1 hr preop, then 1 gtt q.i.d. for 7 days‡ NS p < 0.03 (day 52 only) NS  
Herbort et al218 (1993) Argon laser trabeculoplasty (53) 0.1% Diclofenac (1 gtt preop and postop, then q.i.d. for 4 days) ND p < 0.05 (days 1, 2, 4, 7) ND  


*Placebo controls.
†Only different at 24 hours.
‡ Compared flurbiprofen 0.03% and dexamethasone 0.1% with placebo.
NS, not different statistically; ND, not done.