TABLE 5. Prophylaxis of Cystoid Macular Edema with Topical Nonsteroidal Anti-Inflammatory Drug Treatment: Double-Masked, Randomized, Placebo-Controlled Studies
| Authors | Dose regimen | Examination time | Angiographic CME† | Improved vision† | NSAID |
| Miyake et al239 (1980)* | 1 gtt t.i.d. for 2 wk after surgery | 1–2 mo 4–7 mo 12–18 mo |
Decreased Decreased Same |
Yes No No |
1% Indomethacin in sesame seed oil |
| Yannuzzi243 (1981)* | 1 qt q.i.d. for 4–6 wk after surgery | 5 wk 10 wk 52 wk |
Decreased Same Same |
No No No |
1% Indomethacin suspension |
| Kraff, Sanders, Jampol et al235 (1982)* | 1 gtt q.i.d. for 9 mo after surgery | 2–12 mo | Decreased | No | 1% Indomethacin suspension |
| Flach, Stegman, Graham96 (1990) | 1 gtt t.i.d. for 19 days after surgery | 1 mo | Decreased | No | 0.5% Ketorolac solution |
| Solomon, et al246 Flurbiprofen-CME Study Group I (1995)* |
1 gtt q.i.d. 2 days before surgery and for 3 mo after surgery | 21–60 days and 120–240 days | Decreased | Yes (Contrast sensitivity) No (Snellen) |
0.03% Flurbiprofen 1% Indomethacin suspension |
*Studies included steroids concurrently.
†NSAID treatment vs. placebo treatment.
CME, cystoid macular edema; NSAID, nonsteroidal anti-inflammatory drugs.