Moreover, topical application of CX3CL1 inhibited CNV at 2 weeks, together with enhanced intraocular expression of TSP-1 and ADAMTS-1 but not VEGF. Thus, these observations indicate that intraocular infiltrating CX3CR1-positive macrophages can dampen alkali-induced CNV by producing anti-angiogenic factors, such as TSP-1 and ADAMTS-1, and suggest the potential efficacy of CX3CL1 against alkali-induced CNV.
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