| 【摘要】 目的 探讨眼眶NK/T细胞淋巴瘤病人的临床表现，诊断和治疗方法。方法 从1982～1994年收集我院住院手术、经病理证实为眼眶NK/T细胞淋巴瘤7例，复习病人病历资料，手术方式，治疗方法，切除的病理标本作HE、免疫组织化学染色。结果 7例病人眼球突出、活动受限或固定，视力下降或失明；内眦部和眼睑皮肤红肿、溃烂腔洞形成；CT 检查见眶内侧边界欠清、密度不均的肿块。病理活检见肿瘤内有大量淋巴细胞浸润和坏死组织，CD3、CD45RO、CD57和KI-67免疫组织化学染色阳性。治疗 眶内肿瘤切除，局部放射和全身化学治疗，效果欠佳。结论 眼眶NK/T细胞淋巴瘤少见，其特点是发病急，进展快，破坏性大，预后差。最后确诊需借助于组织病理学和免疫组织化学检查。
【Abstract】 Objective To investigate clinical manifestation, diagnosis and treatment method of orbital NK/T cell lymphoma . Methods 7 patients were collected with orbital NK/T cell lymphoma conformed by surgical biopsies during 22 years. We reviewed records, surgical model and treatment method. Surgical specimen processed with HE and immunohistochemical stain. Results 7 patients had eyeball proptosis, motive inhibition or fixation and visual acuity decrease or no light perception. Skin of inner canthus and eyelids appeared red swollen, ulceration with cave formation. CT scan revealed the tumor with uneven density and unclear border. Tremendous lymphocytes infiltration and tissue necrosis in the tumor showed in the biopsy tissue. LCA、CD45RO、CD57 immunohistochemical stain were positive. Conclusion Orbital NK/T cell lymphoma was rare. The characteristics were a highly aggressive clinical course and severe destruction with poor prognosis. The final diagnosis depended on HE and immunohistochemical stain. |
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