| 目的: 了解异常睑板腺分泌物和干眼症的关系。
方法: 在门诊连续观察68例共136眼。常规检查视力和矫正视力、眼球前段和眼底检查。进行泪膜破裂时间(BUT)，SchirmerⅠ试验和角膜虎红染色（rb）并评分, 观察记录睑板腺分泌物的性质。按病情轻重将干眼症分为轻度和重度。
结果：蛋清样分泌物28眼，奶黄样分泌物26眼，颗粒状分泌物30眼，牙膏状分泌物52眼。干眼症指标3项显示，在蛋清样，奶黄样，颗粒状和牙膏状睑板腺分泌物中，BUT积分和rb积分呈阶梯状依次增高，牙膏状分泌物组的BUT和rb积分明显高于其它3组，（两两比较，P均＜0.01)。各组SchirmerⅠ积分均在1分以下，组间无差别。有54眼（40％）符合干眼症诊断标准，各组患干眼症的构成比依次升高为：蛋清样（2/28）7.1％；奶黄样(4/26)15％；颗粒状(8/30)27％；牙膏状(40/52)77％。颗粒状分泌物发生干眼症高于蛋清样组（p<0.05），而牙膏状分泌物发生干眼症明显高于其它3组(p<0.01）。蛋清样和奶黄样分泌物组无重度干眼症患者，8眼颗粒状分泌物中重度干眼症占2眼，而40眼牙膏状分泌物中19眼发生重度干眼症。牙膏状分泌物发生重度干眼症高于非牙膏状分泌物（p＜0.05）。
结论: 异常睑板腺分泌物影响眼表面的稳定性，其中牙膏状分泌物患者易患干眼症，干眼症程度较其它分泌物组重。
Purpose: To study the relationship between meibomian secretion and dry eye.
Methods: To observe 68 outpatients (136 eyes) consecutively. Routine check up included vision, anterior segment and fundus, scoring of tear break up time (BUT), SchirmerⅠtest and rose bengal staining (rb). Recorded the property of meibomian secretion. Defined the dry eye as mild and severe.
Results: Meibomian secretion was sorted as egg-white-like secretion (n=28), milk-yellowish secretion (n=26)，granular secretion（n=30）and toothpaste-like secretion（n=52）. The result declared that BUT and rb scoring stepped up consecutively in the above secretions, that in toothpaste-like secretion was higher than in other groups（all P＜0.01). SchirmerⅠscoring was below 1 at all groups，and there was no difference within groups.
54 eyes (40%) met the criteria of dry eye syndrome, the incidence of dry eye stepped up in groups as egg-white-like secretion（2/28）7.1％, milk-yellowish secretion (4/26)15％，granular secretion (8/30)27％ and toothpaste-like secretion (40/52) 77％,the incidence was higher in granular secretion than in egg-white-like secretion（p<0.05）, while the incidence in toothpaste-like secretion was higher than any of other 3 groups (p<0.01）. There was no severe dry eye in egg-white-like secretion and milk-yellowish secretion, while in 2 out of 8 in granular secretion, and in 19 out of 40 in toothpaste-like secretion. Severe dry eye was more in toothpaste-like secretion than in non toothpaste-like secretion （p＜0.05）.
Conclusion: Abnormal meibomian secretion affects the stability of ocular surface, people with toothpaste-like secretion are prone to dry eye and tends to have a worse dry eye than other secretion groups.
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