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| Retinitis Pigmentosa Patients with Macular Hole: Implications of Pathogenosis and Therapeutic Prognosis |
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| 作者：Zi-Bing … 文章来源：Department of Ophthalmology & Visual Science, Faculty of Medicine, University of Miyazaki. Kihara 5200, Kiyotake, Miyazaki, 889-1692 Japan 点击数903 更新时间：2006/6/29 18:20:23 文章录入：jinzibing 责任编辑：毛进 |
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| Purpose: Macular hole (MH) is a rare event in retinitis pigmentosa (RP). It has been hypothesized that choroidal blood flow abnormalities lead to chronic cystoid macular edema and whereafter induce the macular hole. Herein, we report five cases of RP with MH and investigate the formation of MH and the therapeutic prognosis.
Methods: Five RP patients (three males and two females, aged from 25 to 67 years) with MH were selected. Surgical therapy was performed in four patients with full-thickness MH. Retrospective clinical data including fundus photography, optical coherence tomography (OCT), electroretinography (ERG) and visual field were collected. Follow-up periods varied between 2 months and 6 years.
Results: Clinical characters were emphasized on OCT scanning of the MH patients. The OCT unequivocally demonstrated one patient with impending MH and four patients with full-thickness MH in which one had retinal detachment. A typical vitreous traction was observed in the fellow eye of a patient. A patient with impending hole was demonstrated macular detachment but not macular pseudocyst. Post-surgery follow-up of the four patients showed the complete sealing of the MH and variant visual improvement.
Conclusion: We reported five RP patients with MH which has rarely been reported. Our results suggest that chronic CME may not the mere predecessor to MH formation in RP patients. Surgical management is beneficial for hole sealing and visual recovery. |
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