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| Visual Acuity Change after Intravitreal Triamcinolone in Various Types of Exudative Age-Related Macular Degeneration |
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| 作者：Jost B. … 文章来源：Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the University Heidelberg, Germany 点击数1805 更新时间：2006/7/9 17:13:26 文章录入：无名小卒 责任编辑：毛进 |
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| Objective. To compare the visual acuity change after an intravitreal high-dose injection of triamcinolone acetonide in various types of exudative age-related macular degeneration.
Participants. The interventional comparative case series study included 142 patients (146 eyes) with progressive exudative age-related macular degeneration differentiated into the occult type (n=78; 53.4%), minimal classic type (n=45; 30.8%), predominantly classic type (n=17; 11.6%), and the purely classic type (n=6; 4.1%). Mean follow-up was 9.7 7.0 months (3 – 35.7 months).
Methods. Single intravitreal injection of about 20 mg triamcinolone acetonide.
Outcome measures. Visual acuity, intraocular pressure.
Results. Gain in visual acuity measured at one month (P=0.20), two months (P=0.43), and at three months (P=0.38) after the intravitreal injection of triamcinolone and maximal gain in visual acuity during the whole follow-up (P=0.81) did not vary significantly between the four study groups. Correspondingly, the size of a retinal pigment epithelium detachment was not significantly associated with the change in visual acuity at 1 month (P=0.62), 2 months (P=0.24), 3 months (P=0.96) or the maximal gain in visual acuity during follow-up (P=0.93). The amount of rise in intraocular pressure compared with the baseline value (6.5 7.4 mm Hg) was statistically not associated with the type of subfoveal membrane (P=0.20; 95%CI: -0.52, 2.45).
Conclusions. The change in visual acuity and the rise in intraocular pressure in patients with exudative age-related macular degeneration receiving an intravitreal triamcinolone monotherapy is statistically independent of the type of subfoveal membrane including the size of a retinal epithelium detachment.
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