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| Erythropoietin Levels in Aqueous Humour in Eyes with Exudative Age-Related Macular Degeneration and Diabetic Retinopathy |
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| 作者：Jost B. … 文章来源：(1) Department of Ophthalmology, and (2) Institute for Clinical Chemistry, Faculty of Clinical Medicine Mannheim of the University Heidelberg, Germany 点击数3120 更新时间：2006/7/10 20:29:19 文章录入：毛进 责任编辑：毛进 |
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| Purpose. To evaluate whether the concentration of erythropoietin as another potent ischemia-induced angiogenic factor is elevated in eyes with neovascular maculopathies.
Design. Clinical comparative interventional study.
Participants and Methods. The study included 28 patients with diabetic macular edema, 59 patients with exudative age-related macular degeneration (AMD), and 49 patients with cataract. For all patients, aqueous humour was collected during cataract surgery or during an intravitreal injection of triamcinolone acetonide. Erythropoietin levels were measured using a solid-phase chemiluminescence immunoassay.
Results. The mean concentration of erythropoietin was significantly higher in the diabetic group (60.1 46.7 mUnits/mL; p<0.001) than in the age-related macular degeneration group (22.9 23.2 miili units / mL) and in the control group (22.0 21.0 mUnits / mL; p<0.001). The two latter groups did not vary significantly (p=0.41).
Conclusions. Erythropoietin may be present in considerably higher concentrations in eyes with diabetic macular edema than in eyes with exudative AMD or normal eyes.
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