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| In vivo development of the refractive state and ocular component dimensions in C57BL/6 mice |
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| 作者：周翔天,M… 文章来源：浙江省温州市学院西路270号温州医学院附属眼视光医院 点击数1549 更新时间：2008/3/11 16:09:45 文章录入：毛进 责任编辑：毛进 |
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| Purpose: To investigate refraction, corneal curvature, and axial components and the associations between the refraction and growth of ocular components during the emmetropization in the mouse. Methods: Groups of mice underwent ocular measurements at 22, 25, 29, 35, 47, 53, 67, 81, 95, and 102 days after birth.Measurements included refraction, corneal radius of curvature (CRC), central corneal thickness, anterior chamber depth (ACD), lens thickness (LT), vitreous chamber depth (VCD), retinal thickness, and axial length (AL). Optical coherence tomography was used to measure the dimensions. Results: Refraction was -1.49D at day 22 and the highest relative myopia was at day 25 (-4.6D). The refractive error then increased and reached a hyperopic peak around day 47. The overall change in refraction was significant from 22 to 102 days. All measured ocular components changed significantly during the study period except for corneal and retinal thicknesses. The CRC, ACD, LT, and AL increased from 22 to 47 days. The increase in ACD, LT, and AL continued after 47 days; however, the CRC increased slowly after this age. The ACD became stable around 67 days, and LT and AL at 81 days. Increases of CRC and LT were better correlated to the refraction (R2= 0.25 and 0.24) than were ACD, VCD, and AL.Conclusions: In mouse eyes, myopia developed early and increased rapidly to reach a hyperopic peak around 47 days. The major component related to the refraction was not the growth of vitreous chamber as described in other animals and humans. |
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