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| First report of primitive neuroectodermal tumors
originally in Optic nerve |
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| 作者：DING Zhe… 文章来源：Department of ophthalmology, Chinese PLA General Hospital, Beijing, 100853, China 点击数2273 更新时间：2008/3/11 18:49:44 文章录入：毛进 责任编辑：毛进 |
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| Abstract: Objective To Report primitive neuroectodermal tumors originally in a 10-year-old boy of the left optic nerve. Methods Using ocular B-ultrasound, the orbital MRI scan, HE staining and immunohistochemical methods to have a preliminary observation. RT-PCR of formalin-fixed paraffin-embedded was used to analyze pathological tissue of the left optic nerve. Results Ocular B-ultrasound, the orbital MRI scan results showed that the left optic nerve is obvious thickening; HE staining of the tumor tissue display a Rossettes- corporations structure; Immunohistochemistry report that CD3 (-), CD20 (-), CD99 (+), Desmin (-), GFAP (-), Ki-67 (+ >75%), CK (-); EWS - FLI1 fusion gene expressed in the tumor cells using RT-PCR test. Conclusion We found the primitive neuroectodermal tumors originally in optic nerve, the fusion location is EWS - FLI1. |
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