Purpose  To investigate anterior chamber parameters and biometric factors associated with degree of angle opening after laser peripheral iridotomy(LPI) for narrow angles.
Methods  In this prospective cohort study, patients with narrow angles who were scheduled for LPI were recruited. Anterior chamber parameters by anterior segment coherence tomography(ASOCT) under dark conditions were compared before and after LPI. Only the right eye was used for analysis if both eyes were eligible. Measurements performed by customized software included anterior chamber depth(ACD), iris area, angle opening distance at 500μm(AOD500) anterior to the scleral spur, iris thickness at 750 μm from sclera spur(IT75),trabecular-iris space area 500(TISA500) and iris curvature(I-Curv). Univariate and multivariate analyses were performed to determine the predictive factors of angle opening after LPI.
Results  Eighty one patients with narrow angles were prospectively recruited in this study. The AOD500 increased significantly from 0.128±0.081 mm(before) to 0.209±0.087 mm(after) in the nasal quadrant, and from 0.103±0.067 mm (before) to 0.197±0.071 mm (after) in the temporal quadrant (p<0.001 for both nasal and temporal). I-Curv decreased significantly after LPI(p<0.001). Significant increase was noted in TISA500 before and after LPI(p<0.001). In the multivariate analysis model, increase in AOD500 was positively correlated with age(Standardized β=0.408, p=0.003) and I-Curv (Standardized β=0.277, p=0.033), and was negatively correlated with preoperative iris area (Standardized β=-0.563, p=0.006).
Conclusions  In this hospital-based study on the results of LPI for narrow angle subjects, statistically significant independent predictors of anterior chamber angle widening after LPI were older age, smaller iris area, and steeper iris.