Purpose To evaluate the effects of Glaucoma Progression Analysis (GPA) and Visual Field Index (VFI) used in Humphrey Field Analyzer perimeter (HFA) in follow-up management of glaucoma patients.
Methods  Retrospective studies of the eyes of glaucoma patients and ocular hypertensive patients were made in at least five reliable central visual field results through 24-2 test of SITA-Fast strategy. Progression of the visual field damage was analyzed by visual field progression scaring criteria of Advanced Glaucoma Intervention Study (AGIS) and analyzing indices of GPA software respectively. Agreement between both methods was quantified by kappa analysis.
Results There's a significant relevance between the incidence of the progression of visual field damage evaluated by GPA and the one evaluated by clinical scoring criteria. Furthermore, GPA indicated the test point of abnormal variation with simple triangle symbols, and revealed the possible progressions of visual field with the words of  "Likely Progression", "Possible Progression" or "No Progression Detected"  in progression analysis printouts. GPA indicated the velocity of progressive visual field damages within five years through the regression analysis of VFI relative to age, which give a clear clinical guide to patients for the next therapeutic target.
Conclusions GPA has an excellent efficiency for evaluation of visual field progression, just like clinical scoring criteria of AGIS, and more sensitive, specific and convenient, which has an important guiding effect on the follow-up of either confirmed or suspected glaucoma patients, or ocular hypertension patients.