| Abstract:
Purpose: To investigate the feasibility and the effect of fresh amniotic membrane transplantation in treatment of the severe ocular surface diseases.
Methods: 19 patients of severe ocular surface diseases including 5 patients who had thermal burn, 10 patients who had corneal ulcer, 2 patients who had extensive symblepharon and 2 patient whose conjunctiva healed lately. All patients were operated by single-layer or multi-layers with fresh amniotic membrane and followed for 6-12months.
Results: 19 case did not occur acute rejection, and stable ocular surface were maintained fast .The graft in 5 eyes which had sever hot burned were not dissolved and perforation. 1 case eyeball of burned by iron water with perforation was rescued. The visual acuities were improved to various degrees in 9 cases of corneal ulcer. 1 patient who had corneal ulcer recurred was give up to re-transplantation. Ocular movements were regained in 2 cases of symblepharon.
Conclusions: Fresh Amniotic Membrane Transplantation is effective method for the severe ocular surface diseases, and can reduce the inflammation of the cornea, and prevent ocular surface ulcer perforation and can make the stabilization process fast. It can also decrease corneal neovascularization as well as establish better conditions. It is important to reconstruct the ocular surface disorders that the diseases tissues clear off fully and the amniotic membrane grafts were sutured stability.
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