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| A comparison of the effectiveness of triamcinolone acetonide (TA) and a 2.5% suspension of poly-lacticglycolic acid (PLGA) on visualization during PPV in rabbits |
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| 作者：Qing Pen… 文章来源：Dept.of Ophthalmology, Univ. of California, Irvine, CA, 92697(in America), First hospital of Shanxi Medical University, 030001(in China) 点击数1186 更新时间：2006/5/15 12:42:31 文章录入：Peng Qing 责任编辑：毛进 |
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Purpose
To compare TA and PLGA as visualization agents of the vitreous cortex during standard vitrectomy procedures and to assess residual pharmacologic effects following the procedure in pigmented rabbits.
Methods
Dutch-Belted rabbits were divided into two groups of 5 each. After standard 25 gauge pars plana vitrectomy (PPV), one group received 4 mg TA in 0.1 ml and the other group received 0.1 ml of 5 % PLGA to visualize the vitreous cortex. TA or PLGA was removed with a subtotal vitrectomy and soft tip needle. Forty-eight hours after surgery, VEGF165 (500 ng / 50 ul) was injected intravitreally via a 29 gauge needle to induce retinal vasculopathy and assess a pharmacological action of residual TA or PLGA. Follow-up at baseline and 48 hours after VEGF administration consisted of retinal color fundus imaging, fluorescein angiography and fluorophotometry to assess leak from the retina vasculature.
Results
During vitrectomy, TA and PLGA worked similarly to visualize the VC. FA showed less retinal vessel leak in the TA group than in the PLGA group. Fluorophotometry area under the curve analysis showed a change from baseline of 3 ± 65% in the TA group and 487 ± 260% in the PLGA group.
Conclusions
TA and PLGA are both efficient visualization agents during PPV. TA appears to have residual pharmacological activity 4 days after the procedure.
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