| Objective: To study on the distribution of bacterial keratitis isolates and the resistance to antibiotics in China from 2001 to 2004.
Methods: 1985 specimens from the bacterial keratitis at the Beijing Tong Ren Eye Center were cultured and identified. In vitro susceptibility testing of positive isolates to antibiotics was determined by the Kirby-Bauer disk diffusion method and interpreted according to the National Committee for Clinical Laboratory Standards serum standards.
Results: Out of 1985 specimens, 279 were culture positive. The percentage of positive culture was 14.06%. Gram-positive cocci and gram-negative bacilli represented 42.65% (119/270) and 35.13% (98/279), respectively. Pseudomonas sp. was the most common pathogen (20.07%)., followed by Corynebacterium sp.(16.85%) and Staphylococcus epi .(13.98%). Resistance of the bacteria to ofloxacin, ciprofloxacin, levofloxacin, and tobramycin was 20.2%, 35.9%, 15.5%, and 29.4% respectively. There was no significant change in resistance to four antibiotics for gram-positive bacilli. Gram-negative bacilli showed higher resistance to Ciprofloxacin. Staphycoccus sp. revealed significant resistance to ciproloxacin and streptococcus sp. showed high resistance to tobramycin. The resistance of isolates from older patients (≥60Y) to ciproloxacin, levofloxacin, and tobramycin was higher compared with younger patients (>14 to 59Y).
Conclusion: Staphylococcus sp., Pseudomonas sp., and Corynebacterium sp. were the most common organisms were the most common bacterial keratitis isolates in China. Attentions should be paid to the increase of the resistance to Levofloxacin.
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