| Purpose: To describe the distribution of the retinal vessel diameter in Beijing Eye Study (BES) and to examine the relationship between open-angle glaucoma (OAG) and retinal vessel diameter among baseline participants in the Beijing Eye Study.
Design: Population-based cross-sectional study.
Participants: The study included 4439 subjects out of 5324 subjects invited to participate (response rate: 83.4%) with an age of 40+ years.
Methods: Participants had a detailed eye examination, including stereo optic disc photography. Color optic disc photographs were morphometrically examined. One eye of each participant was randomly selected. A computer-assisted program measured retinal vessel diameters from digitized photographs of selected eyes.
Main Outcome Measures: Open-angle glaucoma was diagnosed from matching visual field defects and optic disc cupping, without reference to intraocular pressure (IOP) level. Ocular hypertension was defined as IOP >21mmHg, without matching glaucomatous optic disc and field changes. Average retinal vessel diameters were summarized as central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE). The lowest quintile of CRAE or arteriole-to-venule ratio was used to define generalized retinal arteriolar narrowing.
Results: Means and standard deviation of CRAE, CRVE, and AVR were 149.79+/-13.41, 223.35+/-19.36, and 0.67+/-0.06 in elderly Chinese in Beijing. The study included 4047 participants, after excluding those with incomplete data, PACG or nonglaucomatous optic nerve diseases. Of persons included, there were 70 eyes with open-angle glaucoma, 149 eyes with ocular hypertension. Eyes with glaucomatous damage had significantly narrowwer retinal arteriolar diameters (137.18+/-16.07 microm) than eyes without glaucoma (150.12+/-13.21 microm, P < 0.001) or eyes with ocular hypertension (150.24+/-13.12 microm, P <0.001), after adjusting for age, hypertension histories, and other confounding variables, including refraction, gender, age and area, eyes with glaucomatous damage were at least 2 times more likely to have generalized retinal arteriolar narrowing than eyes without glaucoma (odds ratio, 2.578; 95% confidence interval, 1.076-6.178). CONCLUSIONS: AVR is smaller in rural population than in urban ones. Males have thinner arterioles than female. These population-based data suggest that generalized retinal arteriolar narrowing, an indicator of localized vascular change, is associated with optic nerve damage caused by OAG.
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