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| Retinal and choroidal thickness in guinea pig eyes: A comparison of structural interfaces between optical coherence tomography and histology |
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作者：傅亚娜,X… 文章来源：浙江省温州市学院西路270号温州医学院附属眼视光医院 点击数：1486 更新时间：2008/3/11 16:14:50 
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| Purpose: This study aimed to define retinal and choroidal thickness of guinea pigs using optical coherence tomography (OCT). Method: The fundus in both eyes of 27 pigmented guinea pigs (3 weeks old) and 5 human volunteers was measured by OCT. The scanning site was 1mm away from the optic disc in guinea pig eyes. Ten animals (20 eyes) underwent histological assessment after the OCT measurement. The scanning sequence and amplitude of OCT reflective profiles were correlated to tissue interfaces in histology. OCT images from 10 human eyes and fundus histology from a donor human eye were also compared to those from the guinea pig eyes.Result: The number of distinct interfaces detected by OCT in guinea pigs was greater than in humans. The choroidal posterior interface was only detectable in guinea pig eyes. The thickness of retina and choroid measured by OCT in guinea pigs was 129.8±9.9μm (Mean±SD) and 111.1±21.6μm, respectively. The retinal thickness by OCT in guinea pigs was 45 to 50% of that in humans. Histological thickness in 4 different regions at posterior pole of the guinea pig eyes varied from 132.7±28.1μm to 142.3±21.1μm for the retina and from 50.8±16.9μm to 56.8±12.0μm for the choroid (p > 0.10 among the 4 regions in the retina or choroid).
Conclusion: Both the retina and choroid can be identified by routine OCT in guinea pig eyes. This provides an opportunity to establish an animal model to monitor changes of the retina and choroidal thickness in vivo. |
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| 会议投稿录入：毛进 责任编辑：毛进 |
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