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| Modulation by Calcium and Chloride of cAMP-Induced Short-Circuit Current Increase in Porcine Ciliary |
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作者：吴仁毅 文章来源：浙江大学医学院附属二院眼科中心，杭州市解放路88号 点击数：1161 更新时间：2007/12/13 
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PURPOSE To investigate how calcium and chloride modulate short-circuit current (Isc) increase induced by 8-bromo-cAMP in isolated porcine ciliary processes.
METHODS In an Ussing-type chamber, peak Isc dose-response curves to the cAMP analogue 8-bromo-cAMP (0.01 µM - 30 µM) were constructed in isolated porcine ciliary processess. The effect of calcium channel blockers/stimulaters or calcium/chloride concentration in the bath solution on the Isc increase induced by cAMP analogue was assessed.
RESULTS Only when applied |
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