Methods To analyze clinical feature of 89 cases of IDON with final diagnosis of PLA general hospital form May 2009 to Dec 2010 retrospectively. Ophthalmological and neurolodical detailed clinical and laboratorial examinations were performed on the patients to make a definite diagnosis. We determined the disease using international accepted diagnostic criteria.

Results  28 of 89 (31.5%) patients with IDON, all of whom had a normal brain MRI and suffered from severe irreversible visual loss, were NMO-IgG seropositive. There are 5/28 males and 23/28 femals in AQP-4seropositive group and 29/61 males and 32/61 femals in AQP-4 negative group. There are 8/28 patient who has simple eye involved and 20/28 patient who has both eyes involved in AQP-4seropositive group and 31/61 patients who has simple eye involved and 30/61 patients who has both eyes involved in AQP-4 negative group. The patient in AQP-4 negative have a better recovery of sight and otherwise with AQP-4 seropositive have a bad sight. 5 cases can develop to NMO and 1 case can develop to MS in AQP-4seropositive group and 1cases can develop to NMO and 2case can develop to MS in AQP-4 negative group in our following times

Conclusion  There are high seropositive rate of AQP-4 in patient in optic neuritis. There is higher chance in the patients who have AQP-4seropositive to develop to NMO. Aquaporin-4 (AQP4) autoantibodies (neuromyelitis optica-IgG (NMOIgG)) may have diagnostic and prognostic value in patients who present with isolated ON.