PURPOSE: To investigate the prevalence of dry eye, the incidence of dry eye related factors and the evaluation of quality of life of patients with dry eye in Wuhancity.

 METHODS: We have collected 131 dry eye patients, among of them, there are 16 cases of Sjogren syndrome(SS). These data were collected from Renmin hosptial ofWuhanUniversityranging from March 2010 to January 2011.We use the survey, containing personal information, case history, symptoms and risk factors, to collect the data. Did the objective examination of ocular surface: including meibomian gland function tests, tear breakup time（BUT）, Lissamine green staining, Schirmer test（SⅠt）. Used the (Ocular Surface Disease Index, OSDI) questionnaire to assess the severity of the ocular surface; Used the MOS 36-item short -form（SF-36) and Scale of Quality Of Life with Visual Impairment（SQOL-DVI) to evaluate the quality of life in dry eye patients. Statistical analysis using SPSS 17.0 package.

RESULTS:

(1)   Assessment of 131 people(The age from 21.9 to 89.1 years old, mean age was 55.10 ± 16.61 years old), 47 male and 84 female. Eye symptoms are most common in the dryness of 113 cases (86.3%), visual fatigue in 77 cases (58.8%) and foreign body sensation in 53 patients (40.5%), the most unusual symptoms is eye pain of 8 cases (6.1%);

(2)   Objective examination of ocular surface: The mean BUT was (7.51 ± 0.99) seconds; the mean SⅠt was (2.96 ± 1.08) mm/5min; the mean staining score was (5.37 ± 1.74) points;

(3)   Dry eye-related risk factors: diabetes(OR = 5.166), contact lens (OR = 5.145), pterygium (OR = 6.625), Meibomian gland trauma or disease (OR = 6.872), trachoma (OR = 3.645) and the use of video terminals (OR = 5.316)

(4)   OSDI score Results: The average score was 48.71 ± 14.31 points, OSDI scores and the results of BUT was a negative correlation, r = -0.34, P <0.0001; SⅠt results were a negative correlation, r = -0.24, P = 0.0065; staining scores were a positive correlation, r = 0.82, P <0.0001;

(5)   SF-36 results: SS patients got lower scores than NSS dry eye patients in these four dimensions: physical functioning (PF), body pain (BP), general health perceptions (GH) and social function (SF). P <0.05, this difference was statistically significant;

(6)   SQOL-DVI results: SS patients got lower scores than other dry eye patients in these four aspects: visual function, physical function, social activities and psychological, P <0.05, the difference was statistically significant.

CONCLUTIONS: The most common symptoms of dry eye in patients were dryness, visual fatigue and foreign body sensation, but the symptoms of red eye and eye pain were rare. Associated risk factors of dry eye include: Meibomian gland trauma or disease, pterygium, the use of video terminals .More severe dry eye patients got the higher scores with OSDI.The results of SF-36 suggest that: SS patients received greater impact than NSS dry eye patients in these four dimensions: physical functioning, pain, general health perceptions and the social functions. The results of SQOL-DVI suggest that: SS patients suffered greater impacts than NSS dry eye patients in these four aspects: symptoms and visual function, physical function, social activities and psychological.

Keywords : Dry eye;  Sjögren syndrome（SS）; Non-Sjögren syndrome（NSS）；quality of life;  OSDI;  SF-36;  SQOL-DVI