最新公告:

  没有公告

您现在的位置: 心灵之窗-眼科医生网 >> 眼科常识 >> 第17届全国会 >> 正文
专题栏目
更多内容
相关文章
更多内容
Common single nucleotide polymorphisms and keratoconus in the Han Chinese population           ★★★
Common single nucleotide polymorphisms and keratoconus in the Han Chinese population
作者:王亚妮 文章来源:西安市第一医院 陕西省眼科研究所 点击数:272 更新时间:2012/9/13

OBJECTIVE: To investigate whether the tSNPs in VSX1, COL4A3, COL4A4 genes were associated with keratoconus in the Han Chinese population.
METHODS: Ninety-seven keratoconus patients and 101 healthy controls were used in this study. All cases were diagnosed on the basis of clinical examination, including corneal stromal thinning, Vogt’s striae, Fleischer’s ring, Munson’s sign, signs of videokeratography, and refractive errors. Twenty-one tSNPs were selected for association study in three genes. SNP genotyping was performed by Sequenom MassARRAY RS1000. Sequenom Typer 4.0 Software, PLINK, Haploview and SHEsis software platform were used to perform data management and analyses.
RESULTS: Three tSNPs in the VSX1 gene were observed to be associated with KTCN risk at a 5% level by χ2 test (rs56157240, p = 0.0499, OR: 6.42, 95% CI: 0.77 - 53.78; rs12480307, p = 0.0499, OR: 6.42, 95% CI: 0.77 - 53.78; rs6050307, p = 1.22×10-7, OR: 0.05, 95% CI: 0.01 - 0.23). Three Haplotypes in the VSX1 gene were found to be associated with risk of KTCN (p < 0.05).
CONCLUSIONS: Our findings confirmed previously reports that polymorphisms in VSX1 gene were associated with risk of KTCN in the Chinese population, suggesting an important determinant of KTCN development by VSX1 gene.

会议投稿录入:毛进    责任编辑:毛进 
  • 上一篇会议投稿:

  • 下一篇会议投稿:
  • 【字体: 】【发表评论】【加入收藏】【告诉好友】【打印此文】【关闭窗口
      网友评论:(只显示最新10条。评论内容只代表网友观点,与本站立场无关!)

    | 设为首页 | 加入收藏 | 联系站长 | 友情链接 | 版权申明 |
    眼科医生网 眼科医生网版权所有 @ 1998-2012
    部分文章和资源来源于网络,如果侵犯了您的版权,请指出! 站长:毛进
    信息产业部备案
    *京ICP备18030162号