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| 新生血管性青光眼患者眼内IL-6和VEGF的定量测定及其临床意义 |
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作者：汤永强 李… 文章来源：重庆医科大学附属第二医院眼科 点击数：1660 更新时间：2005/5/26 21:14:57 
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| 【摘 要】目的：定量测定新生血管性青光眼患者和白内障患者房水及玻璃体内血管内皮细胞生长因子（vascular endothelial growth factor，VEGF）、白细胞介素-6（Interleukin-6，IL-6）的浓度并分析其临床意义。方法：采用酶联免疫吸附测定法，分别测定32例新生血管性青光眼患者（分为两组，其中第Ⅱ组曾接受过全视网膜光凝治疗），18例白内障患者（第Ⅲ组）房水及玻璃体内VEGF、IL-6浓度，所有患者标本均于手术中穿刺所得。结果：第Ⅰ组房水及玻璃体内VEGF、IL-6浓度显著高于其他两组，差异有显著性；而第Ⅱ组与第Ⅲ组相比无显著性差异。结论：眼内VEGF、IL-6浓度增高在新生血管性青光眼的发生过程中起重要作用。
The quantitative measure and clinical signification of VEGF and IL-6 in aqueous humor and vitreous of patients with neovascular glaucoma
【Abstract】Objective: To quantitatively measure and analyze the clinical signification of VEGF and IL-6 in aqueous humor and vitreous of patients with neovascular glaucoma and with cataract. Methods: The samples of 38 cases with neovascular glaucoma (including two groups, with patients in the second group have received laser photocoagulation) and 18 cases with cataract were measured by using enzyme linked immunosobent assay (ELISA) for quantitatively analyzing the concentration of VEGF and IL-6. All the samples were obtained by puncturing from anterior chamber and vitreous during the operation. Results: The concentration of VEGF and IL-6 in aqueous humor and vitreous in the first group were higher than those in the other two groups. There were significant difference between the three groups. But there were no significant difference between the second group and the third group. Conclusion: The enhanced level of intraocular VEGF and IL-6 was regarded to be important for the course of the neovascular glaucoma. |
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