Objectives: To evaluate the safety and efficacy of trabeculectomy with implantation of a biodegradable collagen-glycosaminoglycan matrix in refractory glaucoma patients. Methods: The collagen-glycosaminoglycan matrix was implanted on the top of the scleral flap before closing the conjunctival wound during trabeculectomy in 9 patients. Results: The mean preoperative IOP was 41.2 ± 6.5 mmHg with 2.3 ± 0.5 antiglaucoma medications. Postoperatively, the mean IOP at last follow up (36 months) for all eyes was 17.4 ± 2.1mmHg (57.7% reduction, p < 0.01) with 0.8 ±0.5 antiglaucoma medications. There were no significant intra-operative complications in any patients. Post-operative complications including transient shallow anterior chamber, hyphema, choroidal detachment and hypotony, no endophthalmitis occurred in any patients. Conclusion: Results suggest that this procedure represents a safe, simple, and effective therapeutic approach for treating refractory glaucoma.
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