Purpose To measure the intraocular pressure (IOP) in different sleep positions, and compare with IOP in the sitting position.
Design Prospective，case control study.
Methods Setting: single center clinical practice
Study Population: 32 patients with POAG and 28 normal people.
Observation Procedure: patients had IOP measured in the sitting position and then again in the supine, right lateral decubitus (right-lateral) and left lateral decubitus (left-lateral) positions with a Perkins applanation tonometer. IOPs then were measured again in the sitting postion after1, 5 and 10 minutes.
Main Outcome Measures: IOP in the different posture.
Results In normal subjects, the IOPs of the right eye were 17.5±3.8 (sitting), 19.3±3.1 (supine), 21.7±3.7 (right-lateral) and 21.5±3.7mmHg (left lateral). The IOPs of left eye were 18.4±3.0 (sitting), 19.3±3.1 (supine), 20.7±2.9 (right-lateral) and 22.8±4.0 mmHg (left lateral). In the POAG patients, the IOPs of the right eye were 17.9±3.7 (sitting), 20.6±4.6 (supine), 26.1±7.1(right-lateral) and 26.3±5.9 mmHg (left-lateral). The IOPs of the left eye in these positions were 18.2±3.6 , 20.0±4.1 , 25.6±6.1 and 25.7±6.0mmHg, respectively. IOPs under the right- and left-lateral were higher than that in sitting and supine in both groups. The IOP increases inall positions for POAG patients were significant higher than in normal subjects. The IOP decreased rapidly after returning from the supine to the sitting position. IOPs at 1 minute, 5minutes and 10minutes after returning to the sitting position were not significantly different than the original sitting IOP.
Conclusion the IOP in lateral decubitus positions is significantly higher than the IOP in sitting and supine positons. These differences are greater in POAG. The clinical significance of these data is not known. | 
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